The business-friendly environment found in Preston County has resulted in a range of employers covering several industries. Health care, education, retail, construction, manufacturing, national security, government, and correctional institutions are all represented. The top employers in Preston County for 2021 were:
- Federal Prison System
- Preston County Board of Education
- Mon Health
- The Adjutant General’s Department (Camp Dawson)
- C.W. Wright Construction, Inc.
- Superior Reedsville Filtration, LLC
- Kingwood Center, LLC (Stonerise)
- Preston Contractors, Inc.
- BFS Foods, Inc.