The business-friendly environment found in Preston County has resulted in a range of employers covering several industries. Health care, education, retail, construction, manufacturing, national security, government, and correctional institutions are all represented. The top employers in Preston County for 2022 were:
- Federal Prison System (FCC Hazelton)
- Preston County Board of Education
- Mon Health
- Superior Reedsville Filtration
- C.W. Wright Construction, Inc.
- The Adjutant Generals Department (Camp Dawson)
- Preston Contractors, Inc.
- Preston County Commission
- BFS Foods, Inc.